Extended Data Fig. 3: Attenuation of corticosterone-induced changes in hepatic morphology and adipose tissue by autoantibody-mediated neutralization of ACBP/DBI model.
From: Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome
(a) Representative hematoxylin and eosin stains of liver, white adipose tissue (WAT), and interscapular brown adipose tissue (iBAT) of female C57BL/6J mice treated with corticosterone (CORT; 100 μg/mL or vehicle control (Ctrl) in drinking water, p.o.) for 5 weeks together with KLH-ACBP for autoimmunization or KLH alone both administered i.p. Scale bar equals 40 µm. (b-f) Medium area of visceral WAT (vWAT), inguinal WAT (iWAT), perigonadal WAT (pWAT), iBAT and hepatocytes was assessed in the indicated groups (n=4-5 mice tissue sections/condition). One-way ANOVA with Tukey correction was used for statistical analysis (P-values are indicated). All dot plots depict means ± SEM.
