Extended Data Fig. 4: Attenuation of corticosterone-induced changes in hepatic morphology and adipose tissue by ACBP/DBI mAb-mediated neutralization of ACBP/DBI.
From: Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome
(a) Representative hematoxylin and eosin stains of liver, white adipose tissue (WAT), and interscapular brown adipose tissue (iBAT) of female C57BL/6J mice treated with corticosterone (CORT) (100 μg/mL, or vehicle (Ctrl) in drinking water, p.o.) with or without αACBP (5 mg/kg body weight, i.p.) semiweekly for 5 weeks. Scale bar equals 40 µm. (b-f) Medium area of visceral WAT (vWAT), inguinal WAT (iWAT), perigonadal WAT (pWAT), iBAT and hepatocytes was assessed in the indicated groups (n=4-5 mice tissue sections/condition). One-way ANOVA with Tukey correction was used for statistical analysis (P-values are indicated). All dot plots depict means ± SEM.
