Extended Data Fig. 4: Impact of TCA cycle inhibition on bioenergetic parameters and effector functions.
From: Pivotal role of exogenous pyruvate in human natural killer cell metabolism
Sorted CD56Dim NK cells were cultured for 4 hours in complete medium in the presence or absence of Devimistat or BMS 303141. (a) NAD/NADH ratio, (b) ATP level or (c) the proportion of cells expressing CD107a, IFN-γ and MIP1-β measured by flow cytometry after K562 stimulation are shown (Mean +SD, n = 3 independent donors). One-way ANOVAs were performed with corrections for multiple testing in all panels. Exact p-values are shown.
