Extended Data Fig. 3: Deregulated pathways in ATG5 cKO cerebellum.
From: Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
a,b, ShinyGO v0.741-based GO analysis of Biological Processes (BP)-enriched terms in the cerebellar proteome (p < 0.05 and log2 fold change of <-0.25 > 0.25) at 1 M (a) and 3 M(b). c,d, ShinyGO v0.741-based GO analysis of Cellular Component (CC)-enriched terms in the cerebellar proteome (p < 0.05 and log2 fold change of <-0.25 > 0.25) at 1 M(c) and 3 M (d). e,f, Venn diagram of commonly upregulated (e) and downregulated (f) proteins (p < 0.05 and log2 fold change of <-0.25 > 0.25) in the 1- and 3-months-old ATG5 cKO cerebellum. g,h, ShinyGO v0.741-based GO analysis of Cellular Component (CC)- (g) and Biological Processes (BP) (h) enriched terms in the commonly upregulated and downregulated cerebellar proteome of ATG5 cKO (p < 0.05 and log2 fold change of <-0.25 > 0.25) at 1 M and 3 M. i, MetaboAnalyst-based pathway analysis of significantly upregulated and downregulated metabolites in ATG5 cKO cerebellum (p < 0.05 and log2 fold change of <-0.5 > 0.5) a 1 M. j, MetaboAnalyst-based pathway analysis of significantly upregulated and downregulated metabolites in ATG5 cKO cerebellum (p < 0.05 and log2 fold change of <-0.25 > 0.25) at 3 M. 1 M and 3 M indicate 1 and 3 months of age, respectively.
