Aldolase A is one of the glycolytic enzymes that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an ATP-consuming process. Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic metabolic plasticity of cancer cells.
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Acknowledgements
A.T. was supported by an Emmy Noether Award from the German Research Foundation (DFG, 467788900), the Ministry of Culture and Science of the State of North Rhine-Westphalia (NRW-Nachwuchsgruppenprogramm) and an ERC Starting grant (METATARGET, 101078355). A.T. holds the Peter Hans Hofschneider professorship of Molecular Medicine endowed by the Stiftung Experimentelle Biomedizin.
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Nascentes Melo, L.M., Cansiz, F. & Tasdogan, A. Aldolase A: the broker of glycolysis. Nat Metab 7, 242–244 (2025). https://doi.org/10.1038/s42255-024-01202-9
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DOI: https://doi.org/10.1038/s42255-024-01202-9
