Extended Data Fig. 6: Acute activation of NGOxtr promotes vigilance and reduces locomotor activity.
From: Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
Schematics of the (a) light dark box (LDB), (d) elevated plus maze (EPM) and (g) open field (OF) arena. Gq-NGOxtr made (b) fewer entries into the light and (c) spent less time in the light side of the LDB. Gq-NGOxtr mice (e) made fewer entries and (f) travelled less distance in the EPM. Gq-NGOxtr (h) made fewer center entries and (i) travelled less in the OF. (b,c,e,f) n = 10 CON-NGOxtr, 12 Gq-NGOxtr; (h) n = 14 CON-NGOxtr, 13 Gq-NGOxtr; (i) n = 14 CON-NGOxtr, 12 Gq-NGOxtr. Unpaired, two-tailed t-tests. Schematics (a, d, g) made with Biorender.com.
