Extended Data Fig. 9: Chronic activation of NGOxtr does not induce anxiety-like behavior or reduce social preference.
From: Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
Schematics of the (a) light dark box (LDB), (d) elevated plus maze (EPM) and (g) three-chamber social interaction tests. (b) Entries into and (c) duration of time spent in the light side of the LDB did not differ between groups. (e) Open arm entries and (f) distance travelled in the EPM did not differ between groups. Chronic NGOxtr activation did not affect (h) preference for investigating a novel mouse or (i) distance travelled in the three-chamber social interaction test. n = 8 CON-NGOxtr, 7 Gq-NGOxtr. Unpaired, two-tailed t-tests. Schematics (a, d, g) made with Biorender.com.
