Fig. 7: Kdm2a deficiency reshapes muscle metabolic flexibility.
From: Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity
Inhibition of Kdm2a provides skeletal muscles with enhanced metabolic flexibility to shift fuel use from glucose as the main energy source under a normal diet accompanied by cold challenge to lipids as the main energy source under obese condition by increasing the proportion of STMs, which then enhances the capability of the mice to withstand metabolic stress. These insights hold significant implications for Kdm2a to serve as a viable target against metabolic stress in clinical settings (made with BioRender.com).
