Rabah et al. elegantly show that, in Drosophila, astrocytes signal to neurons with hydrogen peroxide to encode memories. This redox-based communication is disrupted by amyloid-β, a mechanism that potentially underlies cognitive deficits in Alzheimer’s disease.
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Papanikolopoulou, K., Georganta, EM. & Skoulakis, E.M. Memory with a little H2O2 help from astrocyte friends. Nat Metab 7, 236–238 (2025). https://doi.org/10.1038/s42255-024-01212-7
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DOI: https://doi.org/10.1038/s42255-024-01212-7
