Extended Data Fig. 3: The effect of dietary protein-restriction on resting metabolic rate.

(a–c) VO2 baseline and after low protein, high carbohydrates study 1 (LPHC (1)), low protein, high carbohydrates study 2 (LPHC (2)) and low protein, high fat, (LPHF) study, (d–f) Resting metabolic rate baseline and after LPHC (1), LPHC (2) and LPHF, (g–i) Resting metabolic rate related to LBM baseline and after LPHC (1), LPHC (2) and LPHF interventions, (k, j, m) weekly resting metabolic rate during LPHC (1), and LPHC (2) and LPHF followed by high protein diet (HPD). Statistics were applied to bar graphs to test for effect of diets. For a–i a two-tailed paired t-test was conducted. a–i are presented as means and individual values. j–l are presented as individual values. In a, d, g, j: n = 8, in b, e, h, k: n = 8 and in c, f, i, l: n = 6.