Extended Data Fig. 4: Effect of a prolonged protein-restricted diet on HOMA-IR and plasma FGF21 levels, plasma glucose and plasma insulin during a hyperinsulinemic-euglycemic clamp.
(a, b) HOMA-IR during the low-protein, high-carbohydrate (LPHC), low-protein, high-fat (LPHF), and habitual higher protein diet (HPD) interventions. (c, d) Plasma FGF21 levels during a hyperinsulinemic-euglycemic clamp (HEC). (e, f) Plasma glucose concentrations during HEC. (g, h) Plasma insulin concentrations during HEC. a, b Repeated measures one-way ANOVA or in c–h repeated measures two-way ANOVA/mixed-effects model with a Bonferroni post hoc test to test for differences between diet interventions. Data are mean ± SEM. In a: n = 8, in b: n = 6. In c, e, g: n = 5, in d, f, h: n = 6.
