Extended Data Fig. 4: 4HPAA, 3HPP, and 4HPP alleviate adipocyte hypertrophy and hepatic steatosis.
a, Representative images of H&E-stained adipose tissue sections, including iBAT, iWAT, and eWAT, from ND/HFD-fed mice orally treated with or without 4HPAA, 4HPP, 3HPP, and tyrosol on the 10th week of treatment. Scale bars represent 100 μm. b, Serum biomarkers (ALT, AST, TC, LDL-C, and HDL-C) in ND-fed mice (n = 5) and HFD-fed mice orally treated with normal water (n = 14) or water supplemented with 4HPAA (n = 15), 3HPP (n = 12), 4HPP (n = 13), and tyrosol (n = 15) were measured and plotted. Error bars indicate mean ± SEM, two-tailed Mann-Whitney test. Experiments were repeated twice independently with similar results.
