Extended Data Fig. 8: 4HPAA treatment reduces chronic inflammation in gut and serum.
a, Measured B cell compartments in the colons of tested mice over time. For measurement at day 3, 6, and 11, n = 2 mice per group; for day 14, 18, and 20, n = 4 mice per group; for day 16, n = 6 mice per group. b, Representative flow plots of the B cell compartment in the colons of HFD-fed mice treated with or without 4HPAA on the day 16. c, Quantification of percentages of B cell compartments on 16th days (n = 6 mice per group). d-e, Transcription of lipid absorption genes, including Cd36 and Scd1 in the colonic (d) and small intestinal (e) epithelia of tested mice after one month treatment (n = 6 mice per group). f, Serum concentrations of individual cytokines in HFD-fed mice treated with or without 4HPAA (n = 6 mice per group). For a, c, d, and e, error bars indicate mean ± SD, two-tailed Mann-Whitney test. For f, error bars indicate mean ± SEM, two-tailed Student’s t-test. All experiments were repeated twice independently with similar results.
