Fig. 7: 4HPAA treatment reduces chronic inflammation in colonic epithelium.
a, Volcano plot of colon transcripts. Dashed lines denote the cut-off values: fold-change > 2 and log10(P) < −3.5. The top upregulated genes for B cell response and downregulated genes for lipid absorption and metabolism are highlighted in red and blue, respectively. b, Gene set enrichment analysis based on the upregulated and downregulated gene hits. c, Representative images of H&E-stained mouse colon tissue sections. Arrows denote enlarged lymphoid follicles. Scale bar, 100 μm. d, Histological scores for H&E-stained colon sections were assessed on the basis of epithelial disruption, inflammatory cell infiltration and follicular lymphoid hyperplasia (n = 5 mice per group). Data are shown as mean ± s.e.m. Statistical analysis was performed using the two-tailed Mann–Whitney U test. For c and d, experiments were independently repeated twice, with similar results.
