Extended Data Fig. 5: Fertilization in cold season is associated with increased adaptive diet-induced thermogenesis (DIT).
From: Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
(a) Participant profiles of the warm birth and cold birth groups and the warm fertilization and cold fertilization groups in Cohort 4 (n = 23). (b) BAT activity as SUV of FDG for subjects who participated in DIT measurement (Cohort 4). Left, the warm birth group (n = 10) and cold birth group (n = 13). Right, the warm fertilization group (n = 6) and cold fertilization group (n = 17). (c) Nutrient composition of the test meal. Participants ingested the nutritionally balanced food and liquid containing 500 kcal/63 kg body weight (BW). (d) Correlation between FFM and resting EE at thermoneutral 27°C. (e) Postprandial whole-body EE adjusted for FFM in the warm birth (n = 10) and cold birth (n = 13) groups. (f) Postprandial whole-body EE adjusted for FFM in the warm fertilization (n = 6) and cold fertilization (n = 17) groups. (a, b, d-f) Biologically independent samples. (a, b, e, f) Data are mean ± s.e.m.; two-tailed P values by unpaired Student’s t-test (a, b) or two-way repeated measures ANOVA (e, f). (d) Pearson’s correlation coefficient (r) and two-tailed P value.
