Fig. 2: Pre-fertilization-origin activation of BAT preserves higher adaptive thermogenesis in offspring adults.
From: Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
a, Whole-body resting EE and CIT of the warm (n = 23) and cold birth groups (n = 19) (Cohort 3) measured in winter. Left, resting EE adjusted for FFM at thermoneutral condition (27 °C) and after 2-h cold exposure (19 °C). Right, CIT. b, Whole-body resting EE and CIT of the warm (n = 14) and cold fertilization groups (n = 28) (Cohort 3) measured in winter. Resting EE adjusted for FFM at thermoneutral condition (27 °C) and after 2-h cold exposure (19 °C) (left). CIT (right). c, Postprandial changes in resting EE adjusted for FFM (left) and DIT calculated as incremental area under the curve (iAUC, right) for the warm (n = 10) and cold birth groups (n = 13) (Cohort 4). d, Postprandial changes in resting EE adjusted for FFM (left) and DIT calculated as iAUC (right) for the warm (n = 6) and cold fertilization groups (n = 17) (Cohort 4). Biologically independent samples (a–d). Data are mean ± s.e.m.; two-tailed P values by unpaired Student’s t-test or by two-way repeated measures ANOVA (a,b and c,d, right) with post hoc unpaired Student’s t-test (c,d left).
