Fig. 6: Summary illustration of the intergenerational control of BAT metabolic fate and energy homeostasis by preconception cold exposure.
From: Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
Preconception exposure to low outdoor temperature and temperature gap affects offspring’s metabolic phenotype, promoting higher EE in humans. Our findings propose a conceptional theory, named PfOHaD. This concept suggests that environmental factors, such as temperature exposure before conception, can programme physiological traits in offspring, potentially influencing their health outcomes across generations.
