Extended Data Fig. 2: Season of fertilization is the independent determinant of the prevalence of cold-activated BAT in young male adults.
From: Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans
(a) Fluctuation of the prevalence of cold-activated BAT by month of birth. Numbers of participants with high and low BAT are indicated on the graph. (b) Fluctuation of the prevalence of cold-activated BAT by month of fertilization. Number of participants with high and low BAT are indicated on the graph. (c) Logistic regression analysis of BAT activity in Cohort 1. (d) Percentage of detection of cold-induced BAT in various regions in high BAT subjects (n = 259). (e) Percentage of the number of depots with active BAT in high BAT subjects (n = 259). (f) Effect of birth season on the number of active BAT depots in Cohort 1 (n = 356). (g) Effects of fertilization season on the number of active BAT depots in Cohort 1 (n = 356). (a-g) Biologically independent participants. (a, b, d-g) Data are percentage, and one-tailed P values by Fisher’s exact test (f, g). (c) Multivariate logistic regression analysis: adjusted odds ratios (ORs) with 95% confidence intervals (CIs) as error bars and two-tailed P values. * P < 0.05, ** P < 0.01. High BAT coded as 1 and low BAT coded as 0, as the dependent variable. Age: ≤ 22 years old, 23 years old, and ≥ 24 years old were coded as 1, 2, and 3, respectively. BMI: ≤ 20.3 kg/m2, 20.4 to 22.0 kg/m2, and > 22.0 kg/m2 were coded as 1, 2, and 3, respectively. The warm season and cold season of the birth and fertilization are coded as 0 and 1, respectively.
