Extended Data Fig. 7: Chronic olanzapine treatment alters energy homeostasis in C57BL/6 mice.
From: GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice
a, A schematic representation of the experiment. b, changes in Body weight. c, changes in Body composition. d, Changes in blood glucose (left) and AUC (right) of mice subjected to ipGTT. e, Changes in blood glucose (left) and AUC (right) of mice subjected to ipITT. b–e, N = 6 mice per group. f–i, Metabolic cage analysis of food intake (f), physical activity (g), heat production (h) and RER (i). a–i, plot data for female mice; f–i, N = 5 mice per group. j, A schematic representation of the experiment. k, changes in Body weight. l, changes in Body composition. m, Changes in blood glucose (left) and AUC (right) of mice subjected to ipGTT. n, Changes in blood glucose (left) and AUC (right) of mice subjected to ipITT. k–n, N = 6 mice per group. o–r, Metabolic cage analysis of food intake (o), physical activity (p), heat production (q) and RER (r). j–r, plot data for male mice; o–r, N = 5 mice per group. Results are shown as mean ± SEM. P values were determined by Two-way ANOVA followed by Sidak’s multiple-comparison tests in b, c, d (left), e(left), f–i, k, l, m (left), n (left), o–r, or Unpaired two-tailed Student’s t-tests in d (right), e (right), m (right), n (right).
