Extended Data Fig. 1: AATPs suppress the activity of VMHPdyn neurons.
From: GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice
a, b, Mean traces of core (a) and BAT (b) temperature after acute injection of vehicle or Olz (2.5 mg/kg) in male C57BL/6 mice (N = 3 mice for veh group, N = 4 mice for olz group). c, Atypical antipsychotics and their affinities for Htr2c, from https://www.bindingdb.org/ and https://go.drugbank.com. d–i, Mean VMHPdyn GCaMP fluorescence trace during the indicated AATPs treatment. Risperidone (1.5 mg/kg) (d), Clozapine (10 mg/kg) (e), quetiapine (20 mg/kg) (f), aripiprazole (0.5 mg/kg) (g), amisulpride (50 mg/kg) (h), lurasidone (2 mg/kg) (i) (N = 3-4 mice per group). Data are plotted as mean ± SEM. j, Violin plots showing Htr2c, Drd2, Mc4r, Htr2a, Htr2b, Glp1r, and Glp2r expression distributions in Pdyn-expressing clusters, with male and female plotted separately. P values were determined by Two-way ANOVA followed by Sidak’s multiple-comparison tests in a, b. Shaded area indicated time points that are statistically significant compared to vehicle group.
