Extended Data Fig. 5: Alas1 substrates and their precursors accumulate upon heme biosynthesis blockade.
From: Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
a, b) Relative abundance of Alas1 substrates and their metabolic precursors in differentiated WT and Alas1 KO brown adipocytes (a; n = 4 biological replicates per genotype) and primary brown adipocytes treated with vehicle or SA throughout differentiation (b; n = 3 biological replicates). Data shown as mean ± SD. p values vs. WT or vehicle; multiple two-tailed Student’s t-test.
