Extended Data Fig. 2: Related to Figure 2.
From: Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice
. Total expression of fatty acids synthesis pathway genes (a), glycogen synthesis pathway genes (b), and glycolysis pathway genes (c) in each cell cluster. Metabolic pathway genes are retrieved from Kyoto Encyclopedia of Genes and Genomes (KEGG). Fatty acids synthesis pathway genes include Acsl, beg, bgm, CG12170, CG16935, CG3603, CG3961, FASN1, hll, ATPCL, AcCoAS, ACC. Glycogen synthesis pathway genes include AGBE, GlyS, Gyg, Pgm1, Pgm2a, Pgm2b, UGP. Glycolysis pathway genes include Ald1, Ald2, CG12229, CG2964, CG6650, CG7059, CG7069, CG7362, CG9010, CG9961, Eno, Gapdh1, Gapdh2, Hex-A, Hex-C, Hex-t1, Hex-t2, Pfk, Pgi, Pgk, Pglym78, Pglym87, PyK, Tpi. (00 _epithelial_cell n=12066, 01_muscle_cell n=10791, 02_indirect_flight_muscle n=21190, 03_heart_muscle n=381, 04_visceral_muscle_of_midgut n=1064, 05 _intestinal_stem_cell n=4066, 06_enterocyte n=4583, 07 _enterocyte-like n=674, 08_enteroendocrine_cell n=264, 09_cardia n=715, 10_hindgut_A n=2650, 11_hindgut_B n=1732, 12_hindgut_C n=621, 13_fat_body n=6200, 14_oenocyte n=3597, 15_hemocyte n=2468, 16 _tracheal _cell n=2344, 17_malpighian_tubule_principal_cell n=780, 18_salivary_gland n=562, 19_ventral_nervous_system n=7585, 20_cell_body _glial_cell n=1827, 21_follicle_cell n=15600, 22_follicle_cell _stage 9+* n=1994, 23 _stretch_follicle_cell n=779, 24 _stalk_follicle_cell n=1954, 25_cyst_stem_cells n=662, 26_germline_cell_A_unknown stage n=6615, 27_germline_cell_B_germline cyst n=3518, 28 _germline_cell_C_unknown stage n=3130, 29_oviduct n=723, 30_female_reproductive_system_A n=1294, 31_female_reproductive_system_B n=48, 32_neuron_A n=77, 33_neuron_B n=236). Box plots denote the medians, means, and the interquartile range. The whiskers of each box plot are the lowest and highest expression levels.
