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Mitochondria

TMEM65 joins the mitochondrial Ca2+ club

Nature Metabolism volume 7, pages 641–642 (2025)Cite this article

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Garbincius et al. show that TMEM65, a mitochondrial transmembrane protein of unknown function, has a central role in efflux of calcium ions from the mitochondria. Mitochondrial calcium efflux is crucial for maintaining mitochondrial calcium levels, which is important for metabolic homeostasis and mitochondrial health.

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Fig. 1: TMEM65 is an important component of the mitochondrial Ca2+ homeostasis system.

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Authors and Affiliations

  1. Department of Pharmacology, University of Washington, Seattle, WA, USA

    Yasemin Sancak

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  1. Yasemin Sancak
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Correspondence to Yasemin Sancak.

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The author declares no competing interests.

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Sancak, Y. TMEM65 joins the mitochondrial Ca2+ club. Nat Metab 7, 641–642 (2025). https://doi.org/10.1038/s42255-025-01271-4

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