Extended Data Fig. 6: Prediction of significantly altered functional pathways using PICRUSt2 analysis in the duodenum of leptin-treated mice.
From: Rapid modulation of gut microbiota composition by hypothalamic circuits in mice
A total of 79 pathways exhibited statistically significant changes in the duodenum between vehicle-treated and leptin-treated mice at four hours post-treatment. Bar plots on the left side illustrate the mean proportion (%) of each functional pathway, while dot plots on the right side depict the differences in mean proportions (%) between the two groups (n = 8 mice per group). Statistical differences between groups were assessed using Welch’s t-test, and the significance of each pathway is indicated by the corresponding p-values. Pathways are grouped according to specific functional categories, visually represented by a colour code.
