Extended Data Fig. 5: High fat diet feeding causes overweight, hyperglycaemia and plasma hyperleptinemia.
From: Rapid modulation of gut microbiota composition by hypothalamic circuits in mice
a–c. Body weight (A), blood glucose (B), and plasma leptin levels (C) of mice fed with a standard diet (SD) or a high-fat diet (HFD) for 12 weeks. Data is represented as mean ± SEM (A, SD n = 14 mice and HFD n = 16 mice; B, SD n = 8 mice and HFD n = 7 mice; C, SD n = 8 mice and HFD n = 6 mice). Statistical significance was determined with a two-tailed t test. ****p < 0.0000. d. Microbial α-diversity (Shannon index) of the gut microbiota in vehicle- and centrally leptin-treated mice following 12 weeks of HFD, assessed at two- and four-hours post-treatment (n = 10 mice per group). Boxplots display the range from the first to the third quartile (box) and the median (centre line), while the whiskers extend to the minimum and maximum values.
