Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolic reprogramming

Starvation induces metabolic hepatocyte reprogramming

Nature Metabolism volume 7, pages 864–866 (2025)Cite this article

Subjects

The liver performs gluconeogenesis, the de novo production of glucose during extended fasting and starvation. A study by Okada et al. now highlights spatiotemporal metabolic reprogramming in hepatocytes during metabolic transitions between feeding states.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Spatiotemporal expression of metabolic genes across the liver under different nutritional states.

References

  1. Petersen, M. C., Vatner, D. F. & Shulman, G. I. Nat. Rev. Endocrinol. 13, 572–587 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ben-Moshe, S. & Itzkovitz, S. Nat. Rev. Gastroenterol. Hepatol. 16, 395–410 (2019).

    Article  PubMed  Google Scholar 

  3. Droin, C. et al. Nat. Metab. 3, 43–58 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Martini, T., Naef, F. & Tchorz, J. S. Annu. Rev. Pathol. 18, 439–466 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Okada, J. et al. Nat. Metab. https://doi.org/10.1038/s42255-025-01269-y (2025).

  6. Gallage, S. et al. Cell Metab. 36, 1371–1393.e7 (2024).

    Article  CAS  PubMed  Google Scholar 

  7. Russell, J. O. & Monga, S. P. Annu. Rev. Pathol. 13, 351–378 (2018).

    Article  CAS  PubMed  Google Scholar 

  8. Sun, T. et al. Cell Stem Cell 28, 1822–1837.e1810 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Uno, K. et al. PLoS Biol. 23, e3002955 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Gougelet, A. et al. Hepatology 59, 2344–2357 (2014).

    Article  CAS  PubMed  Google Scholar 

  11. Saponara, E. et al. Am. J. Pathol. 193, 161–181 (2023).

    Article  CAS  PubMed  Google Scholar 

  12. Stekovic, S. et al. Cell Metab. 30, 462–476.e6 (2019).

    Article  CAS  PubMed  Google Scholar 

  13. Ben-Moshe, S. et al. Nat. Metab. 1, 899–911 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Halpern, K. B. et al. Nature 542, 352–356 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gribben, C. et al. Nature 630, 166–173 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland

    Coenraad F. Slabber & Jan S. Tchorz

Authors
  1. Coenraad F. Slabber
    View author publications

    Search author on:PubMed Google Scholar

  2. Jan S. Tchorz
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Jan S. Tchorz.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Slabber, C.F., Tchorz, J.S. Starvation induces metabolic hepatocyte reprogramming. Nat Metab 7, 864–866 (2025). https://doi.org/10.1038/s42255-025-01286-x

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s42255-025-01286-x

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research