Extended Data Fig. 2: CONSORT diagram for COVit-2. | Nature Metabolism

Extended Data Fig. 2: CONSORT diagram for COVit-2.

From: Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19

Extended Data Fig. 2

ITT, intention-to-treat; PP, per-protocol; RFITT, participants with at least one risk factor for severe COVID-19; RFPP, participants from RFITT with per-protocol compliance. The main reasons for exclusion of screened subjects were exceedance of the 7-day time window after the first positive PCR test, complete lack of symptoms, rejection of the trial by the subject, or vaccination against SARS-CoV-2. Refusal of potential subjects to participate occurred during the multi-step registration and verification process, usually after they had fully understood the comprehensive requirements of the trial. Reasons for withdrawal from the trial were mostly non-compliance and worsening of COVID-19.

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