Extended Data Fig. 9: The metabolic phenotypes show signatures in other pathways. | Nature Metabolism

Extended Data Fig. 9: The metabolic phenotypes show signatures in other pathways.

From: Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism

Extended Data Fig. 9

Concentrations of amino acids are higher in Region 2 (oxidative) in both human GB sections and neurospheres. The concentrations of fatty acids and PPP intermediates are higher in Region 1 and Region 3 (which are both more glycolytic than Region 2). There are fewer metabolites shown in the neurosphere data because the DESI-Orbitrap data was acquired over a greater m/z range (70-1000 m/z) while the human data was acquired over a narrower range (70-280 m/z). This reduces the sensitivity of detection in neurospheres, particularly of the less abundant metabolites.

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