Extended Data Fig. 4: Absolute drug effects corresponding to Fig. 2. | Nature Metabolism

Extended Data Fig. 4: Absolute drug effects corresponding to Fig. 2.

From: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

Extended Data Fig. 4

Body weight development of 47-week old male C57BL/6 J wildtype (WT) and Per-Gipr knockout (KO) mice treated daily with either vehicle, acyl-GLP-1 (10 nmolkg), or the combination of acyl-GLP-1 (10 nmol/kg) and a GIPR antagonist (1,500 nmol/kg) (n = 8 each group) (a). Body composition (n = 8 each group) 47-wk old male C57BL/6 J DIO wildtype and Per-Gipr KO mice after 25 days of treatment (b,c). Data in panel a was analyzed by 2-way ANOVA with Bonferroni’s post-hoc test for comparison of individual time points. Data in panel b,c were were analyzed using 1-way ANOVA. Data represent mean ± SEM; asterisks indicate * p < 0.05; ** p < 0.01 and *** p < 0.001. Individual p-values are shown in the Data Source file, unless p < 0.0001.

Source data

Back to article page