Fig. 6: Correlation of drug-induced effects on DVC neuron gene expression differences.
a–f, A comparison of log fold-change differences in gene expression in DVC neurons between male DIO C57BL/6J WT mice (DIO cntrl.) treated with acyl-GIP or the GIPR antagonist (ant.) (a), GIPR antagonist versus acyl-GLP-1 (b), acyl-GIP versus MAR709 (c), acyl-GLP-1 versus MAR709 (d), GIPR antagonist versus MAR709 (e) or acyl-GLP-1 versus acyl-GIP (f) (n = 6 mice per group, from which n = 3 mice were pooled to receive n = 2 independent biological replicates per group). g–i, UMAP representation of gene expression of DVC neurons coloured by neuron type (g), and with expression of Glp-1r (h) and Gipr (i). j,k, Heat maps showing mean gene expression of Glp-1r and Gipr in DVC neuronal populations (j) and experimental group (k), and with the colour corresponding to log-normalized expression values scaled to the maximum of each gene.
