Fig. 1: Functional mapping of brain regions activated by food odours.
From: A food-sensitive olfactory circuit drives anticipatory satiety
a, Voxel-based analyses of the ratio of tissue and plasma glucose concentrations (CE/CP) based on 18F-FDG kinetics in brains of fasted C57BL/6N mice not exposed or exposed to food odours (NCD). The yellow–red and blue–white scales represent the magnitude of P values from a voxel-wise paired t-test indicating food odour-induced activated regions (yellow–red) or inhibited regions (blue–white; paired two-tailed Student’s t-test; n = 12 mice). Atlas-based anatomical brain regions analysed are indicated by dashed blue lines. b, Quantification of 18FDG metabolism of regions depicted in a. Data are represented as the mean ± s.e.m. *P ≤ 0.05 (dark bars indicate mice not exposed to food odours; orange bars indicate mice exposed to food odours). AHN, anterior hypothalamic nuclei; AON, anterior olfactory nuclei; ARH, arcuate nucleus of the hypothalamus; CBX, cerebellar cortex; CENT3, cerebellum lobule III; CP, caudoputamen; DLG, dorsal lateral geniculate nucleus; DMH, dorsomedial nucleus of the hypothalamus; DpG, deep grey layer of the superior colliculus; ENT, entorhinal cortex; GPe, globus pallidus; HipAnt, anterior section of hippocampus; HipPost, posterior section of hippocampus; HipV, ventral section of hippocampus; IC, insular cortex; La, lateral amygdaloid nucleus; LH, lateral hypothalamus; M2, secondary motor cortex; MnPO, median preoptic nucleus; Mo5, trigeminal motor nucleus; MOB, main olfactory bulb; MPOA, medial preoptic area; NDBAnt, anterior section of diagonal band nucleus; NDBPost, posterior section of diagonal band nucleus; NTS, nucleus of the solitary tract; OTAnt, anterior section of olfactory tubercle; OTPost, posterior section of olfactory tubercle; PAG, periaqueductal grey area; PF, prefrontal cortex; PH, posterior hypothalamic area; PirAnt, anterior section of piriform cortex; PirPost, posterior section of piriform cortex; POR, Superior olivary complex; PrL, prelimbic cortex; PVT, paraventricular thalamic nucleus; RNAnt, anterior section of the reticular nucleus; RNPost, posterior section of the reticular nucleus; S1Ant, anterior section of primary somatosensory cortex; S1Post, posterior section of primary somatosensory cortex; SIM, simple lobule; SMT, submedial nucleus of the thalamus; SPIVAnt, anterior section of spinal vestibular nucleus; SPIVPost, posterior section of spinal vestibular nucleus; SUM, supramammillary nucleus; VMH, ventromedial nucleus of the hypothalamus; VO, ventral orbital cortex; VP, ventral pallidum; VPM, ventral posteromedial nucleus of the thalamus; VTA, ventral tegmental area.
