Extended Data Fig. 1: Unbiased whole-brain mapping of food odour activation.
From: A food-sensitive olfactory circuit drives anticipatory satiety
a) Representative images and quantification comparison of food odour-induced (normal chow diet, NCD) FOS immunoreactivity (IR) in fasted C57BL/6 N mice [unpaired two-tailed Student’s t-test; n = 4-8 mice]. Scale bar: 100 µm. b) Schematic representation of brain regions showing a food odour-induced (NCD) increased glucose uptake and FOS immunoreactivity. c) Heatmap of 18FDG and number of FOS-positive cells per region normalized to overall average 18FDG and cell number in mice exposed to no odours. Data are represented as mean ± SEM. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 and, ****p ≤ 0.0001. ACO, anterior cortical amygdaloid nucleus; AONAnt, anteromedial part of the accessory olfactory nucleus; AONPost, posteromedial part of the accessory olfactory nucleus; ARH, arcuate nucleus of the hypothalamus; BST, bed nucleus of the stria terminals; DMH, dorsomedial nucleus of the hypothalamus; MOBD, dorsal main olfactory bulb; MOBV, ventral main olfactory bulb; MO, medial orbital cortex; MPOA, medial preoptic area; OPT, olivary pretectal nucleus; OT, olfactory tubercle; PAG, periaqueductal grey area; PirAnt, anterior section of the piriform cortex; PirPost, posterior section of the piriform cortex; PrL, prelimbic cortex; PVAnt, anterior section of paraventricular thalamic nucleus; PVPost, posterior section of paraventricular thalamic nucleus; PVH, paraventricular hypothalamic nucleus; Re, reuniens thalamic nucleus; SCh, suprachiasmatic nucleus; SN, substantia nigra; VMH, ventromedial nucleus of the hypothalamus; VO, ventral orbital cortex; VTA, ventral tegmental area.
