Extended Data Fig. 7: Mitochondrial age induced transcriptome and methylome analysis.
From: Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells
a, Unbiased GO enrichment analysis of gene expression changes induced by dm-aKG treatment in ISCs. b, Schematic of WGoxBS-Seq experimental flow form Snap labelled cells. c, Genome wide distribution of differentially methylated cytosines between ISCsmito-O and ISCsmito-Y. d, Genome wide distribution of differentially hydroxymethylated cytosines between ISCsmito-O and ISCsmito-Y. e, Distribution of differentially methylated cytosines between ISCsmito-O and ISCsmito-Y across genomic elements. f, Distribution of differentially hydroxymethylated cytosines between ISCsmito-O and ISCsmito-Y across genomic elements. g, Unbiased GO enrichment analysis of differentially methylated (left) and hydroxymethylated (right) cytosines between ISCsmito-O and ISCsmito-Y showing top ten most enriched.
