Extended Data Fig. 4: Metabolic contribution to patient-PDX matching.
From: Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
(a) Heatmap of metabolite-specific contributions to patient-PDX matching. The heatmap displays the Δdk values (difference between matched and average non-matched Euclidean distances) for each of the 143 metabolites across 171 matched patient-PDX pairs. Columns represent metabolites, while rows correspond to individual patient-PDX matches. Metabolites with negative Δdk (blue) contribute to greater similarity in matched pairs, while positive Δdk (red) indicate divergence. The variability in metabolite contributions across pairs reflects heterogeneity in patient-PDX metabolite profiles. (b) Histogram of metabolite contributions to similarity. The histogram summarizes the number of metabolites (Δdk < 0) contributing to greater similarity for each matched patient-PDX pair. The majority of matches exhibit 90–130 metabolites with Δdk < 0, indicating that most non-host-related metabolites play a role in driving patient-PDX resemblance.
