Extended Data Fig. 7: ScRNA-seq analysis of CD11b+ cells during the chronic stage post-MCAO. | Nature Metabolism

Extended Data Fig. 7: ScRNA-seq analysis of CD11b+ cells during the chronic stage post-MCAO.

From: Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke

Extended Data Fig. 7

a, Uniform manifold approximation and projection (UMAP) of extracted CD11b⁺ cells from sham and MCAO mice, showing distinct cellular distributions between groups. b, Bar graphs depicting the proportion of each undefined cluster among CD11b⁺ cells, highlighting changes in cell populations following MCAO. c, UMAP colored by inferred cluster identity, illustrating transcriptional heterogeneity in CD11b⁺ cells from sham and MCAO mice. d, Bar graphs illustrating the distribution of defined immune and microglial clusters, revealing group-specific differences in subpopulation abundance. e, Dot plot displaying selected differentially expressed genes for each cluster. Dot size represents the percentage of expressing cells; Color represents average gene expression level, highlighting key transcriptomic alterations. f, Subclustering UMAP showing the distribution of microglial clusters in MCAO and sham groups, identifying distinct microglial subtypes. g, Bar graphs showing the proportion of each microglial cluster, demonstrating MCAO-induced shifts in microglial subpopulations.

Back to article page