Extended Data Fig. 1: FGF21 and receptor-complex expression across the human body. | Nature Metabolism

Extended Data Fig. 1: FGF21 and receptor-complex expression across the human body.

From: Mitochondrial and psychosocial stress-related regulation of FGF21 in humans

Extended Data Fig. 1

Mean transcript levels (normalized Transcript Per Million, nTPM) for (a) FGF21 together with its (b) high affinity receptor FGFR1 (all isoforms) and its obligate co-receptor (c) β-Klotho (KLB) expression across 48 human tissues, from the GTEx v8 RNAseq dataset. Datapoints represent the mean from 21 to 803 individuals per tissue. Tissues are grouped and color-coded by their systemic functions and location. The five tissues with the highest and lowest expression are annotated. See Supplemental Table 2 for corresponding values. Two-sided Wilcoxon signed rank test showed that liver FGF21 expression is 104.2-fold higher (p < 0.0001) than the second highest tissue, skeletal muscle, and 123.7-fold higher than the average of all human tissues. Note: The relatively uniform expression of FGFR1 (all isoforms) and KLB across vascular, digestive, and glandular tissues, along with two brain regions is consistent with circulating FGF21 having a broad signaling in human physiology.

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