Extended Data Fig. 1: FGF21 and receptor-complex expression across the human body.
From: Mitochondrial and psychosocial stress-related regulation of FGF21 in humans

Mean transcript levels (normalized Transcript Per Million, nTPM) for (a) FGF21 together with its (b) high affinity receptor FGFR1 (all isoforms) and its obligate co-receptor (c) β-Klotho (KLB) expression across 48 human tissues, from the GTEx v8 RNAseq dataset. Datapoints represent the mean from 21 to 803 individuals per tissue. Tissues are grouped and color-coded by their systemic functions and location. The five tissues with the highest and lowest expression are annotated. See Supplemental Table 2 for corresponding values. Two-sided Wilcoxon signed rank test showed that liver FGF21 expression is 104.2-fold higher (p < 0.0001) than the second highest tissue, skeletal muscle, and 123.7-fold higher than the average of all human tissues. Note: The relatively uniform expression of FGFR1 (all isoforms) and KLB across vascular, digestive, and glandular tissues, along with two brain regions is consistent with circulating FGF21 having a broad signaling in human physiology.