Extended Data Fig. 2: Morning to afternoon dynamics of FGF21 across groups. | Nature Metabolism

Extended Data Fig. 2: Morning to afternoon dynamics of FGF21 across groups.

From: Mitochondrial and psychosocial stress-related regulation of FGF21 in humans

Extended Data Fig. 2

(a) Two-sided Mann-Whitney’s U-test comparing fasting and fed FGF21 levels (pg/ml) between Controls (n = 65) and MitoD subgroups (3243A>G, n = 18; MELAS, n = 3-4; Deletion, n = 12). In the AM–Fasting state, the 3243A>G group was 0.8-fold higher (M = 427.6 pg/ml, P = 0.004) than Controls (M = 235 pg/ml), whereas the Deletion group was 3.6-fold higher (M = 1088 pg/ml, P < 0.0001). In the PM–Fed state, all MitoD groups were significantly higher than Controls (M =109 pg/ml): 3243A>G was 1.8-fold higher (M = 304 pg/ml, P = 0.0005), MELAS was 1.6-fold higher (M = 284 pg/ml, P = 0.006), and Deletion was 8.5-fold higher (M = 1035 pg/ml, P < 0.0001). Error bars represent standard error of the mean (SEM) (b) Hedge’s g comparing MitoD subgroups to Controls at each time point. (c) Fasting (AM) to fed (PM) change in individual participants’ FGF21 (pg/ml) levels with the group difference expressed as percent difference between time points. Two-sided paired Wilcoxon tests showed significant decreases from fasting-AM to fed-PM levels in Controls (n = 61, P < 0.0001, Median: AM = 173.8 pg/ml, PM = 79.08 pg/ml) and the MitoD group combined (n = 30, P = 0.0005, Median: AM = 535.4 pg/ml, PM = 309.1 pg/ml). When split by subgroup, there was a significant decrease in the m.3243A>G point mutation group only (n = 18, P = 0.004, Median: AM = 307 pg/ml, PM = 191.6 pg/ml).

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