Extended Data Fig. 5: Demographic and metabolic variations in serum FGF21 levels by group: Analysis by sex, age, body composition, and metabolic markers.
From: Mitochondrial and psychosocial stress-related regulation of FGF21 in humans

(a) Violin plot showing FGF21 (pg/ml) between females and males for each group. Solid line marks median and dashed lines mark first and third quartiles (IQR). A two-sided Kruskal-Wallis test with Dunnās multiple comparisons revealed no difference in FGF21 levels between females (n = 64) and males (n = 34). (b) Two-sided Spearmanās correlations between age and fasting FGF21 (pg/ml) by group. Error bands represent 95% confidence intervals. (c) Two-sided Spearmanās correlations between fasting FGF21 levels (pg/ml) and different body composition factors in Controls and MitoD participants. Percent body fat was significantly correlated with FGF21 in both groups (Controls, n = 63, P = 0.046, and MitoD, n = 34, P = 0.013), whereas fat mass was only significantly correlated in Controls (n = 63, P = 0.015). Error bands represent 95% confidence intervals. (d) Forrest plot depicting two-sided Spearmanās correlations coefficients between fasting FGF21 and metabolic biomarkers in Controls and MitoD participants; all measurements are Log10 transformed. Circles represent Spearmanās coefficients and error bars represent 95% confidence intervals. In Controls (n = 65), FGF21 was positively correlated with blood glucose (P < 0.0001), total cholesterol (P = 0.016), and insulin (P = 0.026), and negatively correlated with HDL (P = 0.0043). The MitoD group showed no significant correlation with any metabolic biomarkers. P < 0.05 (*), P < 0.01 (**), P < 0.001 (***), P < 0.0001 (****).