Reduced mitochondrial activity during development triggers a specific superoxide signal that downregulates the biosynthesis of unsaturated fatty acids. This metabolic shift limits lipid peroxidation, preserving nuclear envelope integrity and delaying ageing in Caenorhabditis elegans and in mammalian cells.
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This is a summary of: Chen, P. X. et al. Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism. Nat. Metab. https://doi.org/10.1038/s42255-026-01452-9 (2026).
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Mitochondrial superoxide signals shield the nucleus to delay ageing. Nat Metab (2026). https://doi.org/10.1038/s42255-026-01461-8
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DOI: https://doi.org/10.1038/s42255-026-01461-8
