Fig. 6: Multi-state protein design.
From: Efficient protein structure generation with sparse denoising models
a, Schematic of the structure editing procedure for multi-state protein design. b, Example partially successful multi-state design. c, Scatter plots of AlphaFold 2 scRMSD values for parent and child sequences with pLDDT > 75. Failed sequences are marked in grey, partial successes (parent and at least one child successful) are marked in purple and successful designs are marked in blue. d, Examples of successful multi-state designs. Generated structures for parent and child proteins are shown in grey; the predicted structures are coloured by their corresponding child protein. The N-terminal part is coloured purple and the C-terminal part is blue. AlphaFold 2 scRMSD values are reported for each parent and child design based on n = 1,000 backbones per condition.
