Extended Data Fig. 1: Distribution of damaged genes in BE and EAC.
Damaged genes per sample in EAC WGS/WES cohorts (n = 779 patients) with any type of damaging alterations (A), homozygous deletions (B), gene amplifications (C), double hits (D) and damaging SNVs and indels (E). Number of damaged genes per sample in P-BE (n = 218 patients) and NP-BE (n = 63 patients) with any type of damaging alterations (F), homozygous deletions (G), gene amplifications (H), double hits (I) and damaging SNVs and indels (J). FHCRC, Fred Hutchinson Cancer Research Center; NP-BE, non-progressor Barrett’s esophagus; EAC, esophageal adenocarcinoma; P-BE, progressor Barrett’s esophagus; SNVs, single nucleotide variants; TCGA, The Cancer Genome Atlas; UoC, University of Cambridge. All boxplots show first and third quartiles, whiskers extend to 1.5X the interquartile lower and upper range and the line indicates the median.
