Extended Data Fig. 4: Antitumour effect of intratumoural CD47-LLO in 4T1Br4 and EO771 models. | Nature Cancer

Extended Data Fig. 4: Antitumour effect of intratumoural CD47-LLO in 4T1Br4 and EO771 models.

From: An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy

Extended Data Fig. 4

a, Schematic of experiments involving intratumoural (IT) injections of CD47-LLO or anti-CD47 in syngeneic orthotopic 4T1Br4 breast cancer models. b, 4T1Br4 tumour volumes after IT injection of anti-CD47 or CD47-LLO. n = 4 for intratumoural CD47-LLO, n = 4 for intratumoural anti-CD47. c-d, Flow cytometry analysis of CD4+ (c) and CD8+ (d) tumour-associated lymphocytes in EO771 tumours at day 16 after tumour inoculation in each group. e, Flow cytometry analysis of SIINFEKL–H2Kb tetramer+CD8+ T cells within the tumour microenvironment. Data shown represent mean ± s.e.m. (b) analyzed by two-way analysis of variance with Tukey’s multiple comparisons test. Panel a created by modifying graphics from BioRender.com.

Source data

Back to article page