Extended Data Fig. 5: Biodistribution of CD47-LLO after intratumoural and intraperitoneal administration in vivo. | Nature Cancer

Extended Data Fig. 5: Biodistribution of CD47-LLO after intratumoural and intraperitoneal administration in vivo.

From: An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy

Extended Data Fig. 5

a, Representative fluorescence images and b, quantification of EO771 tumour-bearing mice taken at predetermined times after intratumoural injection of IR800CW-tagged CD47-LLO (25 μg). n = 2 mice. Bilateral tumours enclosed in circles. c, Ex vivo fluorescence images and d, quantification of tumour and major organs collected at 24 h after intratumoural administration. n = 2 mice. e, Quantification of EO771 tumours taken at predetermined times after intraperitoneal injection of IR800CW-tagged CD47-LLO (100 μg). n = 4 mice. f, Ex vivo fluorescence images and g, quantification of tumour and major organs collected at 36 h after intraperitoneal administration. n = 4 mice. Data shown represent mean ± s.d. (b, d, e, g) analyzed by two-sided unpaired Student’s t test (g).

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