Extended Data Fig. 6: Tumour-associated CD45+ cells detected by single-cell RNA sequencing. | Nature Cancer

Extended Data Fig. 6: Tumour-associated CD45+ cells detected by single-cell RNA sequencing.

From: An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy

Extended Data Fig. 6

a, Uniform manifold approximation and projection (UMAP) of all single cells from 3 treatment groups color-coded by cluster from IgG (n = 3), anti-CD47 (n = 4), or CD47-LLO (n = 4) treated tumours. b, Heatmap of 20 differentially expressed genes in clusters, ranked by false discovery rate (FDR) from the 3 treatment groups. c, Dot plot showing marker expression for different clusters from the 3 treatment groups. Dot size indicates the percentage of cells in each cluster expressing the gene and colors indicate the average expression levels.

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