Extended Data Fig. 8: Differentially expressed genes define tumour-associated macrophages clusters. | Nature Cancer

Extended Data Fig. 8: Differentially expressed genes define tumour-associated macrophages clusters.

From: An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy

Extended Data Fig. 8

a, Dot plot depicting the top 10 differentially expressed genes per macrophage cluster. Dot size indicates the percentage of cells in each cluster expressing the gene and colors indicate the average expression levels from IgG (n = 3), anti-CD47 (n = 4), or CD47-LLO (n = 4) treated tumours. b, Dot plot depicting the differential expression of relevant genes for cluster assignments per macrophage cluster from the 3 treatment groups. c, Gene set enrichment analysis utilizing the Gene Ontology Biological Process (GOBP) gene set for tumour-associated macrophages with heatmap displaying the ten most upregulated and downregulated pathways in each cluster ranked by their normalized enrichment scores (NES) from the three treatment groups.

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