Extended Data Fig. 6: Analysis of tumor evolution.
Evolutionary plot per patient in the a, discovery cohort (n = 7) and b, validation cohort (n = 14) illustrating somatic mutations occurring at baseline, post-surgery, and at relapse. The y-axis represents the accumulated number of mutations across the cohort. The presence of mutations over time is depicted by colors, where gray indicates mutations appearing at baseline but representing unselected subclones lost after surgery. Progressing up the chromatic scale from green to purple signifies mutations persisting over time, considered clonal. Conversely, mutations emerging after surgery until the patient’s relapse are depicted in shades of red, indicating clones arising due to tumor evolution during this period. c, EMT scores for metastatic and primary tissues. Distribution of EMT scores for primary tissues and metastatic tissues for each patient. Negative scores can be interpreted as indicating a mesenchymal phenotype, whereas positive scores indicate an epithelial phenotype.
