Extended Data Fig. 7: Mutational signatures in the discovery cohort.
a, Identification of mutational signatures at relapse (n = 25 patients). Each bar represents an individual patient, with colors corresponding to different mutational signatures, as indicated in the legend. The upper panel provides patient metadata, including age, batch, tumor location, gender, MSI status, and stage. b, Comparative distribution of mutational signatures between plasma at both baseline and relapse (n = 12 patients). The distribution of mutational signatures at both time points is displayed, allowing visualization of changes in signature composition over time. Each bar represents an individual patient, with colors corresponding to different mutational signatures, as indicated in the legend. The upper panel provides patient metadata, including age, batch, tumor location, gender, MSI status, and stage.
