Extended Data Fig. 8: Evaluation of TMB.
a, TMB comparison between tissue samples at baseline and relapse in the discovery cohort (n = 17; two-sided Wilcoxon test; p-value = 0.7910). The minimum values are the smallest number of TMB of the cohort. The first quartile above the whiskers represents the data point that separates the lowest 25% of the data from the rest. The center line per box plot represents the median value among the data points. The third quartile just on top of the box plot separates the lowest 75% of the data points from the highest 25%. The maximum value represents the highest TMB of the cohort. b, TMB comparison between plasma samples at both baseline and relapse in the discovery cohort (n = 12; two-sided Wilcoxon test; p-value = 0.9632). The minimum values are the smallest number of TMB of the cohort. The first quartile above the whiskers represents the data point that separates the lowest 25% of the data from the rest. The center line per box plot represents the median value among the data points. The third quartile just on top of the box plot separates the lowest 75% of the data points from the highest 25%. The maximum value represents the highest TMB of the cohort. c, TMB comparison between plasma samples at both baseline and relapse in the validation cohort (n = 15; two-sided Wilcoxon test; p-value = 0.1070). Each patient is individually compared across different stages. The minimum values are the smallest number of TMB of the cohort. The first quartile above the whiskers represents the data point that separates the lowest 25% of the data from the rest. The center line per box plot represents the median value among the data points. The third quartile just on top of the box plot separates the lowest 75% of the data points from the highest 25%. The maximum value represents the highest TMB of the cohort. d, Spearman correlation (two-sided) analysis between TMB and dN/dS in primary tissue (blue; n = 25; p-value = 0.0785) and relapse (red; n = 17; p-value = 0.0199) within the discovery cohort. P-values and rho scores are reported for each case. The line represents the fitted relationship between the variables, while the shaded band corresponds to the 95% confidence interval around the regression estimate.
