Extended Data Fig. 3: Additional findings of IDH-mutant glioma in ages 0-40.
(A) Age of diagnosis in IDH-mutant astrocytoma (n = 241 patients). P-value calculated using Tukey’s multiple comparison test. (B) Age of diagnosis in IDH-mutant ODG (n = 101 patients). P-value calculated using unpaired t-test (two-tailed). (C) Age of diagnosis of IDH1 p.R132H vs non-canonical IDH mutant tumors in the Toronto cohort (n = 368 patients). P-value calculated using unpaired t-test (two tailed). (D) OS of IDH-mutant astrocytoma based on age of diagnosis in the Toronto cohort (n = 230 patients). P-value calculated using Log-rank test. (E) OS of IDH-mutant astrocytoma with based on ATRX and TP53 status (including MSKCC cohort for those with incomplete phenotype, n = 75 patients). P-value calculated using Log-rank test. (F) OS of IDH-mutant ODG based on age of diagnosis in the Toronto cohort (n = 101 patients). P-value calculated using Log-rank test. (G) OS of IDH-mutant ODG with and without co-occuring TERT promoter mutation (including MSKCC cohort for those without TERT promoter mutation, n = 80 patients). P-value calculated using Log-rank test. (H) Non-canonical IDH mutation and tumor type within the Toronto cohort (n = 48 tumors). (I) OS of IDH-mutant astrocytomas stratified by mutation type and grade (MSKCC cohort included for non-canonical IDH-mutant tumors, n = 253 patients). P-value calculated using Log-rank test. (J) OS of ODGs stratified by mutation type and grade (MSKCC cohort included for non-canonical IDH-mutant tumors, n = 111 patients). P-value calculated using Log-rank test. (K) Multivariate analysis of factors affecting OS in IDH-mutant astrocytoma. P-value calculated using Cox regression, error bars show 95% confidence intervals. (L) Multivariate analysis of factors affecting OS in ODG. P-value calculated using Cox regression, error bars show 95% confidence intervals.
