Extended Data Fig. 2: Characteristics of Toronto 0-40 cohort.

(A) Age at diagnosis divided by sex in 0-40 Toronto cohort (n = 1456 patients). P-value calculated using unpaired t-test (two-tailed). (B) Tumor location in the pediatric ( < 15 years) Toronto cohort (n = 583 patients). (C) Tumor location of IDH-WT tumors in 0-40 Toronto cohort (n = 738 patients). P-value calculated using Tukey’s multiple comparison test. (D) PFS and OS of PLGG in treated vs untreated AYAs (n = 202 patients). P-value calculated using Log-rank test. (E) 2021 WHO diagnosis of tumors in the Toronto pediatric cohort (n = 530 tumors).